“The Whit Whit Fund”
The Whit Whit Fund began very organically. The Posillico men shaved their heads every year for St. Baldrick’s to raise money for pediatric cancer. When Whitney was diagnosed, her cousin decided to start “Team Whitney” to raise money in her honor. In ten days, we raised over $173,000! We then decided to start the “Whit Whit Fund” at Memorial Sloan Kettering Cancer Center. The “Whit Whit Fund” raises money to research pediatric tumor cancers. To date we have raised over $400,000 for a total of over $570,000 for pediatric cancer research!
With the generous money you have given, researchers have been able to make good progress in their proposed research to find new therapies against tumors. They have completed an extensive pooled shRNA screen on different tumor cell lines. The term “shRNA” is an abbreviation for “small hairpin RNA”. Basically, it is a powerful laboratory method to “turn off” a gene to help figure out whether that gene is important or not for that tumor. A “pooled” shRNA screen is especially powerful because it involves multiple shRNA particles targeting many genes at once. Researchers have acquired a pooled shRNA library against over 400 genes, which already have targeted FDA approved drugs available against them. Therefore, if they are able to identify an shRNA, which leads to the reduction of growth in laboratory models, they could potentially move a corresponding FDA approved drug into clinical trials in an efficient and rapid manner. From their initial screen of the three cell lines, they identified 31 shRNA candidates, which demonstrated selective inhibition against tumors as compared to a non-cancer cell line. After validating all 31 of the “hits”, the ones that truly showed activity have been moved into mouse models to study the activity in animal xenografts.
As you can see, you are making a difference! Thank you!
To make a donation, go to:
Or if you prefer to write a check:
Checks should be made payable to MSKCC. Write memo as: “Whit Whit Fund”.
Memorial Sloan Kettering Cancer Center
Office of Development
Attn: Colleen Hanley
885 Second Ave. 7th Fl.
New York, NY 10017
Tax ID is 13-1924236.